2-Fluoropyridine-4-boronic acid → HCID 58362625, compound

Participants

Reaction Steps

General experimental procedure (A) for Suzuki coupling with 2-fluoropyridin-4-ylboronic acid was followed. Reaction was performed on a 40 mg scale of 2-chloropyrimido[1,2-a]benzimidazole. The residue was purified by HPLC (acetonitrile/water) to give 6.2 mg (12%) of T732 as a white solid. 1H NMR (CD3OD): δ 9.91 (1H, d, J=7.2 Hz), 8.47-8.53 (2H, m, overlapped), 8.39 (PH, d, J=7.2 Hz), 8.25 (1H, m), 8.04 (1H, m), 7.95 (1H, d, J=8.4 Hz), 7.89 (1H, m), 7.76 (1H, m); MS: 265 (M+H+).

Provenance & Evidence