Sodium Hydroxide → HCID 178516346, compound

HRID 2361507Notes

Reaction equation

HRID 2361507 reaction equation
[OH-:1].[Na+].ClC(Cl)(Cl)[C:5]1[CH:10]=[CH:9][N:8]2[C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=[C:7]2[N:6]=1>C(#N)C>[N:6]1[C:7]2[N:8]([C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:9]=[CH:10][C:5]=1[OH:1]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58362479HCID 58362479, compound

Product 1

HCID 178516346HCID 178516346, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Sodium hydroxide (36.5 ml, 36.5 mmol) was added to a solution containing 2-(trichloromethyl)-benzo[4,5]imidazo[1,2-a]pyrimidine (8.04 g, 28.1 mmol) in Acetonitrile (Volume: 122 ml). Heated the reaction to 90 C for 30 minutes. Cooled the reaction to room temperature and concentrated. Added ice to the resulting residue, followed by 35 mL of 1M HCl. Filtered the solid and dried under vacuum to afford crude benzo[4,5]imidazo[1,2-a]pyrimidin-2-ol (5.2 g, 28.1 mmol, 100% yield).

Workup

  1. temperatureHeated
  2. customthe reaction to 90 C for 30 minutes
  3. temperatureCooled
  4. customthe reaction to room temperature
  5. concentrationconcentrated
  6. filtrationFiltered the solid
  7. customdried under vacuum

Sources & evidence

ORD record
ord-20435265506d481984f80f3594002810
Source dataset
uspto-grants-2014_04
Patent number
US08691187B2

Reaction notes

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