3-Fluoro-1-propanol → HCID 67300806, compound

Participants

Reaction Steps

The title compound was prepared using General Procedure S from 4-(4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)aniline and 3-fluoropropan-1-ol on a 0.03 mmol scale. N-(3-Fluoropropyl)-4-(4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)aniline (T693) was obtained as a orange solid (3.9 mg, 33%). 1H NMR (400 MHz, DMSO-d6): δ 8.25 (d, J=8.8, 2H), 8.07 (s, 1H), 7.94 (d, J=8.4 Hz, 1H), 7.88 (d, J=8.0 Hz, 1H), 7.57 (t, J=7.6 Hz, 1H), 7.46 (t, J=7.6 Hz, 1H), 6.81 (t, J=5.2 Hz, 1H), 6.76 (d, J=8.8 Hz, 2H), 4.64 (t, J=5.6 Hz, 1H), 4.53 (t, J=5.6 Hz, 1H), 3.28 (m, 2H), 1.97 (m, 2H); MS (ESI) m/z [M+H]+389.

Provenance & Evidence