2-Hydroxyethyl acrylate → Demannose

Participants

Reaction Steps

A 40 mol % mannose polymer was prepared as follows. Allyl α-D-mannopyranoside (1.77 g, 8.0 mmol), 2-hydroxyethylacrylate (1.36 g, 11.7 mmol), N-(3-aminopropyl)methacrylamide hydrochloride (89.6 mg, 0.5 mmol) and 2,2′-Azobis-[2-(2-imidazolin-2-yl)-propane]dihydrochloride (23.7 mg, 0.073 mmol) were added into a 50 ml round bottom flask, followed by addition of water (28.8 ml). The mixture was dissolved under magnetic stirring at room temperature. After purging with nitrogen for 5 min, the mixture was heated to 60° C. and polymerized at that temperature for 12 hours. Upon cooling a slightly yellow and viscous solution was obtained. This solution was dialysed (25 k MWCO regenerated cellulose) overnight against water, and freeze-dried to obtain a white fluffy polymer.

Provenance & Evidence