1,4-Dioxane hydrochloride → HCID 21054030, compound

HRID 2361574Notes

Reaction equation

HRID 2361574 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8]2([S:14][CH2:13][CH2:12][CH2:11][S:10]2)[CH2:7][N:6]1[C:15](=[O:29])[CH:16]([NH:21]C(OC(C)(C)C)=O)[C:17]([CH3:20])([CH3:19])[CH3:18])=[O:4].Cl.O1CCOCC1>O1CCOCC1>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8]2([S:10][CH2:11][CH2:12][CH2:13][S:14]2)[CH2:7][N:6]1[C:15](=[O:29])[CH:16]([NH2:21])[C:17]([CH3:18])([CH3:19])[CH3:20])=[O:4]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 20805597HCID 20805597, compound

Product 1

HCID 21054030HCID 21054030, compoundYield 110.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Boc protected amine 28 (243 mg) in dioxane (1 mL) was treated with a 4.ON HCl/dioxane solution (2 mL) and stirred for 2 hours at room temperature. The mixture was concentrated in vacuo, slurried in CH2Cl2 and evaporated in vacuo to give 208 mg (100%) of desired 2-(2-amino-3,3-dimethyl-butyryl)-6,10-dithia-2-aza-spiro[4.5]decane-3-carboxylic acid methyl ester 29 as a white solid and as the HCl salt. Mass Spec. MH+=347.1.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-e549a6f004f546179f36541283fdb75e
Source dataset
uspto-grants-2014_04
Patent number
US08691758B2

Reaction notes

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