Ethyl 2-(diphenylmethyleneamino)acetate → HCID 86685800, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2R)-6-methyloct-7-en-2-yl 4-methylbenzenesulfonate (15 g, 50.6 mmol) and N-(diphenylmethylene)glycinate ethyl ester (13.53 g, 50.6 mmol) in toluene (120 mL) was added LiHMDS (60.7 mL, 60.7 mmol, 1M solution in THF) at 0° C. The reaction mass was allowed to come to room temperature heated at 110° C. for 2 h. The reaction mass was cooled to room temperature, quenched with water and extracted with ethyl acetate (200 mL×3). The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to get crude compound (14.5 g). The crude compound was taken to the next step without further purification. MS: MS m/z 392.1 (M++1).

Provenance & Evidence