反应详情

温度

100 °C

To a solution of 4.92 g (0.02 mole) of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepin-5-(4H)one in 35 ml of dimethylformamide was added 7.55 g (0.041 mole) of potassium phthalimide. The mixture was stirred for 5 hr at 100° C. and left standing at room temperature overnight. Dimethylformamide was removed by rotary evaporation (80° C. vacuum pump). The residue was taken up in 100 ml of chloroform and washed with water (2×30 ml) and 2M potassium hydroxide (2×3 ml). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated by rotary evaporation (70° C., water aspirator). The 6.26 g of crude product was recrystallized from isopropyl alcohol to give 2.60 g (36%) white cyrstalline powder, m.p. 146°-47° C.

1. waitleft
2. waitstanding at room temperature overnight
3. customDimethylformamide was removed by rotary evaporation (80° C. vacuum pump)
4. washwashed with water (2×30 ml) and 2M potassium hydroxide (2×3 ml)
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated by rotary evaporation (70° C., water aspirator)
8. customThe 6.26 g of crude product was recrystallized from isopropyl alcohol
9. customto give 2.60 g (36%) white cyrstalline powder, m.p. 146°-47° C.