Trifluoroacetic acid → Uracil Arabinoside

Participants

Reaction Conditions

Reaction Steps

500 mg (2.23 mmol) of the above product 2 is taken as the starting material to immerse in 5 mL of dimethyl formamide. 70 mL of trifluoroacetic acid (0.05N) is added with continuously stirring at 80° C. The solution is concentrated under reduced pressure by removing the residual part of the solution after the completion of the reaction, and then purified by rapid column chromatography (MeOH/CHCl3=1:3). A white powder product (1-(β-D-arabinofuranosyl)-pyrimidin-2,4(3H)-dione) 3 is obtained. Its weight and yield are 510 mg and 95% respectively.

Provenance & Evidence