1,4-Dioxane → HCID 86712035, compound

Participants

Reaction Conditions

Reaction Steps

600 mg (1.21 mmol) of the above compound 5 as a starting material, 1.42 g (4.32 mmol, 3.6 eq) of dimethyl tin (Sn2Me6) and 22 mg (0.03 eq) of bis-triphenylphosphine palladium dichloride are dissolved in 36 mL of 1,4-dioxane, with continuously stirring at 100° C. After the starting material disappears, the solution is concentrated under reduced pressure, and then purified by rapid column chromatography (EtOAc/n-hexane=1:1). A white solid product (1-(2′,3′,5′-Tri-O-acetyl-β-D-arabinofuranosyl)-5-trimethylstannylpyrimidin-2,4(3H)-dione) 6 is obtained. Its weight and yield are 500 mg and 75%, respectively.

Provenance & Evidence