Sodium methanolate methanol → HCID 86712034, compound

Participants

Reaction Conditions

Reaction Steps

250 mg (0.45 mmol) of the above product 6 as the starting material is dissolved in 15 mL of MeOH and cooled to 0° C. Then 5 mL of 0.01N NaOMe/MeOH is added with continuously stirring. After the starting material completely disappears, a cationic exchange resin (Dowex 500 WX8-400, H+form) is used to neutralize. After filtration, the solution is concentrated at reduced pressure at 30° C. to obtain a product (1-(β-D-arabinofuranosyl)-5-trimethylstannylpyrimidin-2,4(3H)-dione) 7. Its weight and yield are 140 mg and 80% respectively.

Provenance & Evidence