2,4-Difluoroacetophenone → 2-(2,4-difluorophenyl)propan-2-ol

HRID 2361639Notes

Reaction equation

HRID 2361639 reaction equation
[CH3:1][Mg+].[Br-].[CH3:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=1[F:14])=[O:6]>C(OCC)C>[F:14][C:8]1[CH:9]=[C:10]([F:13])[CH:11]=[CH:12][C:7]=1[C:5]([OH:6])([CH3:1])[CH3:4]

Participants

4

Reactant 2

HCID 677702,4-DifluoroacetophenoneHCID 178418689HCID 178418689, compound

Product 1

HCID 106547612-(2,4-difluorophenyl)propan-2-olYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

MeMgBr (1.83 ml of a 3M solution in diethyl ether, 5.5 mmol) was added dropwise to a solution of 2,4-difluoroacetophenone (782 mg, 5.0 mmol) in diethyl ether (20 ml) at 0° C. The reaction was warmed to room temperature and after 1 hour was quenched and washed with water (2×20 ml), dried (MgSO4) and concentrated under reduced pressure to give the title product as colourless oil (800 mg, 93%).

Workup

  1. customwas quenched
  2. washwashed with water (2×20 ml)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-96741c61fd8841c1928833b3b17e2d9b
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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