反应详情

4-Chloro-2-hydroxy-pyridine (247 mg, 1.91 mmol), Ag2CO3 (1.58 g, 5.74 mmol) and MeI (0.13 ml, 2.11 mmol) were heated in a sealed tube at 50° C. for 16 hours and then filtered through celite and concentrated at reduced pressure. The residue was purified by FCC (Pentane/Diethyl ether with gradient, 99:1 to 95:5) to provide the title compound as colourless oil (160 mg, 58%).

1. filtrationfiltered through celite
2. concentrationconcentrated at reduced pressure
3. customThe residue was purified by FCC (Pentane/Diethyl ether with gradient, 99:1 to 95:5)