HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 44462713, compound → HCID 44476426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 44462713 | HCID 44462713 | — |
| Reactant | 5-Chloro-N-(cyclopropylmethyl)-2-pyridinecarboxamide | HCID 58243439 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44476426 | HCID 44476426 | 240% |
Reaction Steps
In a similar fashion (Route 20, GP I; except using DMF instead of DMSO as solvent), 1-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-ol (50 mg, 0.20 mmol) and 5-chloro-N-(cyclopropylmethyl)pyridine-2-carboxamide (84 mg, 0.40 mmol) gave the title compound as colourless oil (25 mg, 0.48 mmol, 0.047 mmol, 23%) after purification by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691804B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-cf64c50efdf74628a8d472cca747a83d |
| Source note | uspto-grants-2014_04 |