HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 44477405, compound → HCID 44476428, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 44477405 | HCID 44477405 | — |
| Reactant | 5-chloro-N-methylpyridine-2-carboxamide | HCID 57583999 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44476428 | HCID 44476428 | 66.7% |
Reaction Steps
In a similar fashion (Route 20, GP I; except using DMF instead of DMSO as solvent), 1-[(4-cyclobutylpiperazin-1-yl)carbonyl]azetidin-3-ol (150 mg, 0.63 mmol) and 5-chloro-N-methylpyridine-2-carboxamide (214 mg, 1.26 mmol) gave the title compound (156 mg, 0.42 mmol, 66%) as white solid after purification by FCC [SiO2 eluting with DCM/MeOH/NH3 98:2:0.5].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691804B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-8f751e7f34d54416ac15752443b3346c |
| Source note | uspto-grants-2014_04 |