3,4,7,8-Tetramethyl-1,10-phenanthroline → HCID 44477080, compound

HRID 2361657Notes

Reaction equation

HRID 2361657 reaction equation
CC1C=NC2C(C=1C)=CC=C1C=2N=CC(C)=C1C.[CH:19]1([N:23]2[CH2:29][CH2:28][CH2:27][N:26]([C:30]([N:32]3[CH2:35][CH:34]([OH:36])[CH2:33]3)=[O:31])[CH2:25][CH2:24]2)[CH2:22][CH2:21][CH2:20]1.[F:37][CH:38]([F:47])[O:39][C:40]1[CH:45]=[CH:44][C:43](I)=[CH:42][CH:41]=1>>[CH:19]1([N:23]2[CH2:29][CH2:28][CH2:27][N:26]([C:30]([N:32]3[CH2:33][CH:34]([O:36][C:43]4[CH:44]=[CH:45][C:40]([O:39][CH:38]([F:47])[F:37])=[CH:41][CH:42]=4)[CH2:35]3)=[O:31])[CH2:25][CH2:24]2)[CH2:22][CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 742653,4,7,8-Tetramethyl-1,10-phenanthrolineHCID 27370081-(Difluoromethoxy)-4-iodobenzeneHCID 44462713HCID 44462713, compound

Product 1

HCID 44477080HCID 44477080, compound

Procedure

In a similar fashion (Route 21, GP J) except for replacing phenanthroline with 3,4,7,8-tetramethylphenanthroline, 1-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-ol (50 mg, 0.19 mmol) and 1-(difluoromethoxy)-4-iodobenzene (81 mg, 0.3 mmol) gave the title compound as colourless oil after purification by preparative HPLC (47 mg, 57%).

Sources & evidence

ORD record
ord-2d9b901b99d2479e80e04495c1c75830
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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