HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4,7,8-Tetramethyl-1,10-phenanthroline → 6-({1-[(4-Cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-yl}oxy)-2-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4,7,8-Tetramethyl-1,10-phenanthroline | HCID 74265 | — |
| Reactant | 6-Bromo-2-methylquinoline | HCID 522885 | — |
| Reactant | HCID 44462713 | HCID 44462713 | — |
| Product | 6-({1-[(4-Cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-yl}oxy)-2-methylquinoline | HCID 44477162 | — |
Reaction Steps
In a similar fashion (Route 21, GP J) except for replacing phenantroline with 3,4,7,8-tetramethylphenantroline, 1-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-ol (128 mg, 0.51 mmol) and 6-bromo-2-methylquinoline (224 mg, 1.01 mmol) gave the title compound as brown oil after purification by FCC (52 mg, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691804B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-16eda6def6d7498c878e880d35de9223 |
| Source note | uspto-grants-2014_04 |