HCID 58243373, compound → HCID 58243406, compound

HRID 2361696Notes

Reaction equation

HRID 2361696 reaction equation
[CH2:1]([N:3]1[CH2:9][CH2:8][CH2:7][N:6]([C:10]([N:12]2[CH2:15][CH:14]([OH:16])[CH2:13]2)=[O:11])[CH2:5][CH2:4]1)[CH3:2].F[C:18]1[CH:19]=[CH:20][C:21]([C:24]([OH:27])([CH3:26])[CH3:25])=[N:22][CH:23]=1>>[CH2:1]([N:3]1[CH2:9][CH2:8][CH2:7][N:6]([C:10]([N:12]2[CH2:15][CH:14]([O:16][C:18]3[CH:19]=[CH:20][C:21]([C:24]([OH:27])([CH3:26])[CH3:25])=[N:22][CH:23]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 58243373HCID 58243373, compoundHCID 58243400HCID 58243400, compound

Product 1

HCID 58243406HCID 58243406, compound

Procedure

In a similar fashion (Route 20, GP I), 1-[(4-ethyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-ol (90 mg, 0.40 mmol) and 2-(5-fluoropyridin-2-yl)propan-2-ol (95 mg, 0.44 mmol) were used to give the title compound. Crude material (53 mg) after workup gave the title compound as colourless oil (35.6 mg) after purification by preparative HPLC.

Sources & evidence

ORD record
ord-8c4240243d7f4408bf9f7da78f6b38a2
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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