HCID 58243377, compound → HCID 58243440, compound

HRID 2361698Notes

Reaction equation

HRID 2361698 reaction equation
[CH:1]1([N:6]2[CH2:12][CH2:11][CH2:10][N:9]([C:13]([N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[O:14])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.F[C:21]1[CH:22]=[CH:23][C:24]([C:27]([OH:30])([CH3:29])[CH3:28])=[N:25][CH:26]=1>>[CH:1]1([N:6]2[CH2:12][CH2:11][CH2:10][N:9]([C:13]([N:15]3[CH2:18][CH:17]([O:19][C:21]4[CH:22]=[CH:23][C:24]([C:27]([OH:30])([CH3:29])[CH3:28])=[N:25][CH:26]=4)[CH2:16]3)=[O:14])[CH2:8][CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 58243377HCID 58243377, compoundHCID 58243400HCID 58243400, compound

Product 1

HCID 58243440HCID 58243440, compound

Procedure

In a similar fashion (Route 20, GP I), 1-[(4-cyclopentyl-1,4-diazepan-1-yl)carbonyl]azetidin-3-ol (100 mg, 0.41 mmol) and 2-(5-fluoropyridin-2-yl)propan-2-ol (90 mg, 0.41 mmol) were used to give the title compound. Crude material (38 mg) after workup gave the title compound as colourless oil (19.3 mg) after purification by preparative HPLC.

Sources & evidence

ORD record
ord-0dc2f57096324560a7114f6867360c24
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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