Thionyl Chloride → 5-(Chloromethyl)-2-methylpyridine

Participants

Reaction Steps

To a stirred solution of (6-methyl-3-pyridinyl)methanol (166 mg, 1.35 mmol) in dichloromethane (10 ml) was added thionyl chloride (108 μl, 1.48 mmol) giving a colourless solution. After 30 minutes the mixture was concentrated giving a brown solid (240 mg, quant. yield) that was used directly in the next step without purification.

Provenance & Evidence