Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of carbamate 5A (0.10 mmol) in 1,4-dioxane (2 mL) was added a solution of 4 N HCl in dioxane (1.0 mL) and the mixture was maintained at rt for 16 h. The reaction mixture was concentrated and the residue was dissolved in water (2 mL). The aqueous layer was washed with EtOAc (3×5 mL) and concentrated to provide amine (5) in 64% yield as a hydrochloric acid salt. Data: LC/MS (ESR) m/z 292 [M+1]+.

Provenance & Evidence