Sodium Hydroxide → HCID 86673701, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of ketone 1D (10 mmol), NH2OH—HCl (5 mmol), and NaOH (5 mmol) was diluted with EtOH (5 mL) and H2O (1 mL) and the reaction mixture was heated at 80° C. for 16 h. Upon cooling, the reaction mixture was extracted with DCM (10 mL×3) and the combined organic layers were dried (Na2SO4) and concentrated to provide oxime 12A in 90% yield as a solid. The material was used in the next step without further purification. Data: LC/MS (ESR) m/z 295 [M+1]+.

Provenance & Evidence