Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of lactam 14B (0.18 mmol) in 1,4-dioxane (2 mL) was added a solution of 4 N HCl in dioxane (1.0 mL) and the mixture was maintained at rt for 16 h. The reaction mixture was concentrated and the residue was dissolved in water (2 mL). The aqueous layer was washed with EtOAc (3×5 mL) and concentrated to provide amine 14 in 88% yield as a hydrochloric acid salt.

Provenance & Evidence