Methanol → HCID 71008040, compound

Participants

Reaction Steps

A 1.0 M solution of BH3-Me2S in THF (1 5 mmol) was added dropwise to a solution of amide 14B (0.125 mmol) in THF (5 mL). The reaction mixture was heated at reflux for 2 h and was allowed to cool to rt. MeOH (2 mL) was cautiously added and the reaction mixture was concentrated. The residue was triturated with DCM (3×10 mL) and the combined organic layers were dried (Na2SO4) and concentrated to provide amine 15A. The amine was used in the next step without further purification. Data: LC/MS (ESR) m/z 167 [M+1]+.

Provenance & Evidence