Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

The carbamate 16C (0.1 mmol) in 1,4-dioxane (1 mL) was diluted with a solution of 4 N HCl in dioxane (0.5 mL) and the reaction mixture was maintained at rt for 2 h. The reaction mixture was concentrated and the residue was dissolved in water (2 mL). The aqueous layer was washed with EtOAc (3×5 mL) and concentrated to provide amine 16 in 80% yield as a hydrochloric acid salt.

Provenance & Evidence