HCID 136351079, compound → HCID 136195916, compound

Participants

Reaction Steps

20 was synthesized from 19 (0.09 mmol), as described for 9k. The crude material was then stirred at room temperature in AcOH/THF/H2O (4/2/1) solution overnight. The reaction mixture was concentrated under reduced pressure and purified by silica gel chromatography (DCM/MeOH) to yield the title compound. White lyophilized powder. Molecular Formula C26H37FN5O9PS2 1H NMR (DMSO-d6, 400 MHz) δ (ppm) 1.16 (s, 20H), 3.06-3.09 (m, 4H), 3.90-3.91 (d, J=5.40 Hz, 1H), 3.99-4.10 (q, J=6.70 Hz and J=7.00 Hz, 4H), 4.32-4.38 (m, 2H), 4.63 (m, 1H), 6.10-6.14 (d, J=16.93 Hz, 1H), 6.69 (s, 2H), 7.79 (s, 1H), 10.96 (s, 1H) 31P NMR (DMSO-d6, 162 MHz) δ (ppm) −1.91 (s, 1P) 19F NMR (DMSO-d6, 376 MHz) δ (ppm) −156.82 (s, 1F) Scan ES+ 678 (M+H)+.

Provenance & Evidence