2-[3-(Dimethylamino)-1-methoxy-2-propenylidene]malononitrile → 2-Amino-4-Methoxynicotinonitrile

Participants

Reaction Steps

A mixture of D2 (16 g, 90.39 mmol) in NH4OH (100 ml, 30% in water) was heated at reflux for 3 h. After cooling in an ice bath a yellow solid precipitated. The solid was filtered off, washed with cold isopropanol and dried in vacuo to yield compound D3 (10 g, 76%) as a white solid.

Provenance & Evidence