HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-Amino-4-bromopyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2,4-Dibromopyridine-3-carbonitrile | HCID 57459591 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Amino-4-bromopyridine-3-carbonitrile | HCID 58081121 | 26.8% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of compound D7 (32 g, 122.2 mmol) in NH4OH (200 ml, 30% in water) and THF (200 ml) was heated at 100° C. for 12 h. in a PARR pressure vessel. After cooling, EtOAc was added. The organic layer was separated, washed with brine, dried (Na2SO4) and evaporated in vacuo. The solid residue thus obtained was triturated with DCM and then filtered off. The filtrate was evaporated in vacuo to yield compound D8 (6.5 g, 26.8%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691813B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-b0c1fb4648cf453d845e32f0ef0125d0 |
| Source note | uspto-grants-2014_04 |