2-Aminophenol → HCID 66726640, compound

Participants

Reaction Steps

A mixture of 2-aminophenol (2 g, 18.327 mmol), 1,4-dioxa-spiro[4.5]decan-8-one (3.721 g, 23.825 mmol), and sodium triacetoxyborohydride (5.826 g, 27.491 mmol) in DCE (20 ml) and acetic acid (0.2 ml) was stirred at room temperature for 3 h. The reaction mixture was diluted with DCM and washed with NaHCO3 (aqueous sat. solution), dried (Na2SO4) and the solvent was evaporated in vacuo. The solid residue was triturated with diisopropyl ether to yield D19 (3.78 g) as a white solid.

Provenance & Evidence