N-bromobutanimide → HCID 66726429, compound

Participants

Reaction Steps

A solution of intermediate D19 (1 g, 4.011 mmol) and N-bromosuccinimide (0.785 g, 4.412 mmol) in DMF (15 ml) was stirred at room temperature for 1 h. Subsequently, the reaction mixture was washed with NaHCO3 (aqueous sat. solution). The organic layer was separated, dried (Na2SO4), and the solvent was evaporated in vacuo. The crude product was purified by column chromatography (silica gel; DCM/EtOAc 8:2 as eluent): The desired fractions were collected and evaporated in vacuo to yield D22 (0.433 g, 32.89%) as a reddish solid.

Provenance & Evidence