Sodium borohydride → HCID 58081124, compound

Participants

Reaction Steps

A mixture of intermediate D25 (1.3 g, 4.191 mmol) and sodium borohydride (0.476 g, 12.573 mmol) in MeOH (15 ml) was stirred at room temperature for 3 h. Then, the resulting mixture was carefully quenched with NH4Cl (aqueous sat. solution) and extracted with DCM. The organic layer was separated, dried (Na2SO4), and evaporated in vacuo. The residue was triturated with a mixture of diisopropylether/diethylether to yield D26 (1.045 g, 63%) as cis/trans mixture of isomers (34% and 66% respectively)

Provenance & Evidence