HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 11471419, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Phenyl-2-[3-(1H-pyrazol-4-yl)-phenyl]-propionitrile | HCID 11300273 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11471419 | HCID 11471419 | — |
Reaction Steps
To a solution of the product of Example 2 (70 mg, 0.256 mmol, 1.0 equiv) in ethanol (25 ml) was added concentrated ammonia (0.5 ml) and Raney Nickel (approximately 0.5 ml of the water suspension) and the reaction mixture was subjected to a hydrogen atmosphere for 17 hours. The mixture was filtered through Celite® and the mother liquor was concentrated under reduced pressure to give the title compound which was purified by preparative liquid chromatography. (LC/MS: (PS-A) Rt 1.89 [M+H]+ 278.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691806B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-130e13dca855497d9b184733534b0efd |
| Source note | uspto-grants-2014_04 |