Hydrochloric Acid → [4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-yl)-phenyl]-acetonitrile

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	{4-[5-Methyl-1-(tetrahydro-pyran-2-yl)-3-trifluoromethyl-1H-pyrazol-4-yl]-phenyl}-acetonitrile	HCID 59331959	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	[4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-yl)-phenyl]-acetonitrile	HCID 59331945	—

Reaction Steps

To {4-[5-Methyl-1-(tetrahydro-pyran-2-yl)-3-trifluoromethyl-1H-pyrazol-4-yl]-phenyl}-acetonitrile (Example 8B) (35 mg, 0.1 mmol, 1.0 equiv) in ethyl acetate (1 ml) was added HCl in ethyl acetate (1 ml) and the mixture was stirred for 1 hour.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08691806B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-6faee2f3f5a846d78600558fe9ce8a24
Source note	uspto-grants-2014_04