Methyl Methanesulfonate → 3-Amino-2-methyl-5,6-bis(4-methylphenyl)-1,2,4-triazine mesylate

HRID 2361860Notes

Reaction equation

HRID 2361860 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:7]=1.[CH3:22][S:23]([O:26]C)(=[O:25])=[O:24]>CO>[S:23]([OH:26])(=[O:25])(=[O:24])[CH3:22].[NH2:1][C:2]1[N:3]([CH3:22])[NH:4][C:5]([C:15]2[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([CH3:14])=[CH:12][CH:13]=2)[N:7]=1

Participants

4

Reactant 2

HCID 4156Methyl MethanesulfonateHCID 581031023-Amino-5,6-bis(4-methylphenyl)-1,2,4-triazine

Product 1

HCID 866497323-Amino-2-methyl-5,6-bis(4-methylphenyl)-1,2,4-triazine mesylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3-amino-5,6-bis(4-methylphenyl)-1,2,4-triazine (500 mg), methyl methanesulphonate (0.5 cm3) and methanol (10 cm3) was stirred at 40° for 24 hours and then evaporated to dryness. The resulting yellow solid was recrystallised from acetone giving the title compound as pale yellow needles,

Workup

  1. customevaporated to dryness
  2. customThe resulting yellow solid was recrystallised from acetone giving the title compound as pale yellow needles

Sources & evidence

ORD record
ord-74a29c942b2c4c80a58efd4e91438d1d
Source dataset
uspto-grants-2014_04
Patent number
US08691818B2

Reaction notes

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