Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde → (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde | HCID 1476264 | — |
| 반응물 | (2S)-1,1-Diethoxy-2-propanamine | HCID 12398111 | — |
| 생성물 | (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine | HCID 86652569 | 30.3% |
반응 단계
According to the procedure described in the synthesis method of Compound IX-6, (S)-1,1-diethoxypropan-2-amine (Compound XVIII-1) (1.98 g, 13.4 mmol) was reacted with 5-chlorothieno[3,2-b]pyridine-3-carbaldehyde (Compound XIX-1) (1.98 g, 10 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2 to 95:5) to obtain the title compound (996 mg, 30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08691819B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-5abf3cde6b0f49049bea6d8574a50cc9 |
| 출처 메모 | uspto-grants-2014_04 |