HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Pyridinecarboxaldehyde → N-(2,2-Diethoxyethyl)pyridine-4-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| Reactant | 2,2-Diethoxyethylamine | HCID 69524 | — |
| Product | N-(2,2-Diethoxyethyl)pyridine-4-methylamine | HCID 96638 | 44% |
Reaction Steps
According to the procedure described in the synthesis method of Compound IX-2, 2,2-diethoxyethanamine (162.8 ml, 1120 mmol) was reacted with 4-pyridinecarboxaldehyde (120 g, 1120 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: ethyl acetate and ethyl acetate:ethanol=15:1) to obtain the title compound (110 g, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691819B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-ec58fcb1e2af4b3c8e30f41355930003 |
| Source note | uspto-grants-2014_04 |