Piperidine → HCID 67303935, compound

Participants

Reaction Steps

According to the procedure described in the synthesis method of Compound IV-1, (S)-(9H-fluoren-9-yl)methyl 3-(4-tert-butoxyphenyl)-1-((2,2-diethoxyethyl)(quinolin-4-ylmethyl)amino)-1-oxopropan-2-ylcarbamate (Compound III-4) (358 mg, 0.5 mmol) was treated with piperidine and the obtained residue was purified on silica gel column chromatography (eluent: n-hexane:ethyl acetate=9:1, chloroform:methanol=100:0 and 8:2) to obtain the title compound (241 mg, 95%).

Provenance & Evidence