Potassium Carbonate → HCID 45107904, compound

Participants

Reaction Steps

The title compound was prepared from methyl ({[(iodomethyl)oxy]carbonyl}oxy)acetate (excess), (4aS,13aR)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamide sodium salt (80 mg, 0.177 mmol), potassium carbonate (73 mg, 0.531 mmol), and tetrabutylammonium hydrogen sulfate (60 mg, 0.177 mmol), using a similar process to that described in example 1. 1H NMR (CDCl3) δ 10.23 (m, 1 H), 8.38 (s, 1 H), 7.31 (m, 1 H), 6.76 (m, 2 H), 5.98 (d, J=6.4 Hz, 1 H), 5.89 (d, J=6.4 Hz, 1 H), 4.72-4.53 (m, 5 H), 4.28 (m, 2 H), 4.15 (m, 1 H), 3.92 (m, 1 H), 3.73 (s, 3 H), 3.14-3.03 (m, 2 H), 2.82 (m, 1 H), 2.10-1.91 (m, 3 H), 1.68 (m, 1 H). ES+ MS: 577 (M+1).

Provenance & Evidence