Hydrochloric Acid → 3,4-Dichlorobenzaldehyde oxime

Participants

Reaction Conditions

Reaction Steps

3,4-Dichlorobenzaldehyde (1 eq) and hydroxylamine.HCl (4 eq) were suspended in pyridine (10 vol) in a sealed tube. The reaction mixture was stirred at 50° C. overnight under an atmosphere of N2. The reaction mixture was concentrated in vacuo before the addition of EtOAc (10 vol) and 2M citric acid solution (5 vol). The organic layer was separated and washed with citric acid (2×5 vol) and saturated aqueous NaCl solution (5 vol). The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure to yield required 3,4-dichloro-benzaldehyde oxime.

Provenance & Evidence