HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate | HCID 20294522 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetylpiperazine | HCID 7172020 | — |
Reaction Steps
To a solution of compound 1c (15.15 g, 53.69 mmol) in CH2Cl2 (60 mL) was added trifluoroacetic acid (18 mL) at room temperature. The mixture was stirred at room temperature for 18 h. The solvent was removed by evaporation. Ether (100 mL) was added to the residue. The white solid was collected by filtration, washed with ether, and dried under vacuum. The crude compound 1d was used in the next reaction without further purification. MS m/z (M+H+) 183.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691805B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-0fdfff1dca98452792cb215c7b49380e |
| Source note | uspto-grants-2014_04 |