Acetic Acid → HCID 77231503, compound

Participants

Reaction Steps

To the solution of 3-3 (100 mg, 0.37 mmol) in a co-solvent of AcOH (0.2 mL), MeOH (0.2 mL) and THF (1.2 mL) was added Zn/Cu pair (73 mg, 0.6 mmol) and the mixture was stirred at r.t. for 3 h. The mixture was filtered to remove the insoluble solid and the filtrate was diluted with 15 mL of DCM, the combined organic phase was washed with 0.1N HCl aq. and brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep.TLC to give 43 mg of 3-4.

Provenance & Evidence