Hydrochloride methanol → 1-[4-(3-Bromo-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloride methanol	HCID 21893726	—
Reactant	{1-[4-(3-Bromo-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic Acid Tert-butyl Ester	HCID 66665726	—
Solvent	Methanol	HCID 887	—
Product	1-[4-(3-Bromo-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutylamine	HCID 46927085	—

Reaction Steps

To a solution of 4-3 (52 mg, 0.1 mmol) in 1 mL of MeOH was added 4M HCl/MeOH (2 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 4-4. MS (ESI) m/e (M+H+): 420.3

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08691825B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-24b7060d71c649f4a04e54c4c8c18956
Source note	uspto-grants-2014_04