HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → 1-[4-(6-Phenyl-3-vinyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | {1-[4-(6-Phenyl-3-vinyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic Acid Tert-butyl Ester | HCID 66719010 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[4-(6-Phenyl-3-vinyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutylamine | HCID 46927086 | — |
Reaction Steps
To the solution of 4-5 (47 mg, 0.1 mmol) in 1 mL of MeOH was added 4M HCl/MeOH (2 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 4-6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691825B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5f4ea5bc8b674e41b7e806933f3a4fd3 |
| Source note | uspto-grants-2014_04 |