Hydrochloride methanol → HCID 46927247, compound

HRID 2362171Notes

Reaction equation

HRID 2362171 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:22][N:21]4[C:30]([C:39]5[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[C:41]([C:49]([F:52])([F:51])[F:50])[CH:40]=5)=[C:31]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[N:32]=[C:20]4[N:19]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.Cl.CO>CO>[F:52][C:49]([F:50])([F:51])[C:41]1[CH:40]=[C:39]([C:30]2[N:21]3[CH:22]=[C:23]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:18]([C:15]4[CH:16]=[CH:17][C:12]([C:8]5([NH2:7])[CH2:11][CH2:10][CH2:9]5)=[CH:13][CH:14]=4)=[N:19][C:20]3=[N:32][C:31]=2[C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:44]=[C:43]([C:45]([F:46])([F:47])[F:48])[CH:42]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86663523HCID 86663523, compound

Product 1

HCID 46927247HCID 46927247, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the solution of 5-6 (38 mg, 0.05 mmol) in 1 mL of MeOH was added 4M HCl/MeOH (2 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 5-7.

Workup

  1. concentrationThe mixture was concentrated by evaporation
  2. customthe residue was purified by prep.HPLC

Sources & evidence

ORD record
ord-4bfe35065c4b44a2899e7c9f89a30d49
Source dataset
uspto-grants-2014_04
Patent number
US08691825B2

Reaction notes

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