N-bromobutanimide → HCID 66823365, compound

Participants

Reaction Steps

To a solution of compound 9-1 (104 mg, 0.2 mmol) in CHCl3 (5 mL) was added NBS (40 mg 0.22 mmol.) and the mixture was stirred at room temperature overnight. The mixture was diluted with 15 mL of DCM, the combined organic phase was washed with 0.1N HClaq and brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep.TLC to give 83 mg of 9-3.

Provenance & Evidence