Phenylboronic Acid → HCID 66823510, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 9-3 (60 mg 0.1 mmol), phenyl boronic acid (19 mg, 0.15 mmol), aq.Na2 CO3 (2M, 0.25 mmol, 0.12 mL) and Pd(DPPF)Cl2 (10 mg) in dioxane (2 mL) was heated at 100° C. in microwave system under N2 atmosphere for 30 min. After cooling, the mixture was diluted with 15 mL of DCM, the combined organic phase was washed with 0.1N HClaq and brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep.TLC to give 43 mg of 9-5.

Provenance & Evidence