HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2362218Generated: October 31, 2026
Oxalyl chloride → 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE
https://huagongshe.com/reaction/2362218
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Benzothiazole-6-carboxylic acid | HCID 601670 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE | HCID 12208022 | 150.4% |
Reaction Steps
Under a nitrogen atmosphere, benzothiazole-6-carboxylic acid (1.014 g, 5.6 mmol) was dissolved in methylene chloride (25 mL). Five drops of N,N-dimethylformamide was added. Oxalyl chloride (0.5 mL, 5.6 mmol) was slowly added. After 2 hrs, the reaction was heated to 30° C. for 16 hrs. The reaction was concentrated in vacuo to yield benzothiazole-6-carbonyl chloride (19A) (1.665 g, quant., light yellow powder).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08691816B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-a6373812e11c44f29c049f53b21e38f8 |
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| Source note | uspto-grants-2014_04 |
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