HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2362259Generated: November 1, 2026
Ammonium Hydroxide → 5-Amino-2-thiophenecarboxamide
https://huagongshe.com/reaction/2362259
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Methyl 5-amino-2-thiophenecarboxylate | HCID 7131725 | — |
| Product | 5-Amino-2-thiophenecarboxamide | HCID 45084162 | 47.4% |
Reaction Steps
A 18 ml vial was loaded with 5-amino-thiophene-2-carboxylic acid methylester (250 mg, 1.59 mmole) and 5 ml of 30% NH4OH. The vial was sealed and the mixture was heated at 60° C. for 24 hours. The mixture was cooled down and concentrated to give 200 mg crude product, 47.4% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08691816B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-b42d4bcdf5fd4421a3d8a0ce646d6f1f |
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| Source note | uspto-grants-2014_04 |
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