HCID 71293444, compound → HCID 71293442, compound

HRID 2362298Notes

Reaction equation

HRID 2362298 reaction equation
COC(C1[C@@H](C2C=CC(C#N)=CC=2)NC(=S)N(C2C=CC=C(C(F)(F)F)C=2)C=1C)=O.[CH3:31][O:32][C:33]([C:35]1[CH:36]([C:54]2[CH:59]=[CH:58][C:57]([C:60]#[N:61])=[CH:56][CH:55]=2)[N:37]=[C:38]([NH:52][NH2:53])[N:39]([C:42]2[CH:47]=[CH:46][CH:45]=[C:44]([C:48]([F:51])([F:50])[F:49])[CH:43]=2)[C:40]=1[CH3:41])=[O:34]>>[CH3:31][O:32][C:33]([C:35]1[C@@H:36]([C:54]2[CH:55]=[CH:56][C:57]([C:60]#[N:61])=[CH:58][CH:59]=2)[N:37]=[C:38]([NH:52][NH2:53])[N:39]([C:42]2[CH:47]=[CH:46][CH:45]=[C:44]([C:48]([F:49])([F:50])[F:51])[CH:43]=2)[C:40]=1[CH3:41])=[O:34]

Participants

3

Reactant 2

HCID 71293444HCID 71293444, compoundHCID 86678219HCID 86678219, compound

Product 1

HCID 71293442HCID 71293442, compound

Procedure

Intermediate 10 (593 mg) was prepared from Intermediate 9 (3.39, 7.9 mmol) according to an analogous procedure to that described for Intermediate 2.

Sources & evidence

ORD record
ord-ec4b4ddbd22145ae8792ab6e6550dce1
Source dataset
uspto-grants-2014_04
Patent number
US08691826B2

Reaction notes

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