HCID 71293413, compound → HCID 71293446, compound

HRID 2362299Notes

Reaction equation

HRID 2362299 reaction equation
COC(C1[C@@H](C2C=CC(C#N)=CC=2)N=C(NN)N(C2C=CC=C(C(F)(F)F)C=2)C=1C)=O.[CH3:32][O:33][C:34]([C:36]1[CH:37]([C:59]2[CH:64]=[CH:63][C:62]([C:65]#[N:66])=[CH:61][CH:60]=2)[N:38]=[C:39]([NH:53][NH:54][C:55]([O:57][CH3:58])=[O:56])[N:40]([C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([C:49]([F:52])([F:51])[F:50])[CH:44]=2)[C:41]=1[CH3:42])=[O:35]>>[CH3:32][O:33][C:34]([C:36]1[C@@H:37]([C:59]2[CH:64]=[CH:63][C:62]([C:65]#[N:66])=[CH:61][CH:60]=2)[N:38]=[C:39]([NH:53][NH:54][C:55]([O:57][CH3:58])=[O:56])[N:40]([C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([C:49]([F:50])([F:51])[F:52])[CH:44]=2)[C:41]=1[CH3:42])=[O:35]

Participants

3

Reactant 2

HCID 71293413HCID 71293413, compoundHCID 71293442HCID 71293442, compound

Product 1

HCID 71293446HCID 71293446, compound

Procedure

Intermediate 11 (381 mg) was prepared from Intermediate 10 (782 mg, 1.8 mmol) according to an analogous procedure to that described for Intermediate 3.

Sources & evidence

ORD record
ord-0324f43fe80544cc8a38b3dc3b57de2b
Source dataset
uspto-grants-2014_04
Patent number
US08691826B2

Reaction notes

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