N-bromobutanimide → HCID 67960573, compound

Participants

Reaction Steps

To 5-((4-methylquinazolin-2-yl)methyl)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one 13 (386 mg, 1.16 mmol) in CH3CN (10 ml) was added NBS (268 mg, 1.51 mmol) at 0° C., stirred for 1.5 hr. Another 41 mg of NBS was added, stirred for 30 minutes. The reaction was quenched by adding water (15 ml), washed with DCM (2×15 ml). The organic phase was washed with HCl (1 M, 10 ml). The combined aqueous phase was concentrated and purified by flash chromatography (MeOHIDCM, MeOH contains 1% Et3N) to afford 2-bromo-5-((4-methylquinazolin-2-yl)methyl)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one 14.

Provenance & Evidence